Region 10 Player of the Year: Carly Higgins, Cape Fear
Region 10 Coach of the Year: Ryan Deppa. Cape Fear
First Team All-Region
| Position | Number | Name | School |
| Goalkeeper | 1 | Rachel Witkin | Louisburg |
| Defender | 3 | Madison Bolen | Cape Fear |
| Defender | 18 | Sierra Raynor | Cape Fear |
| Defender | 7 | Savannah West | Patrick Henry |
| Defender | 15 | Amanda Gilmore | Spartanburg Methodist |
| Midfielder | 7 | Janessa Annis | Cape Fear |
| Midfielder | 14 | Remi Olalere | Spartanburg Methodist |
| Midfielder | 26 | Morgan Vega | Spartanburg Methodist |
| Midfielder | 8 | Monica Brown | Patrick Henry |
| Forward | 9 | Alaina Capps | Cape Fear |
| Forward | 13 | Cailyn Marietti | Spartanburg Methodist |
Second Team All-Region
| Position | Number | Name | School |
| Goalkeeper | 00 | Jennifer Byrd | Spartanburg Methodist |
| Defender | 6 | Leticia Canterra | Louisburg |
| Defender | 24 | Melani Anderson | Cape Fear |
| Defender | 8 | Stephanie Quirola | Spartanburg Methodist |
| Defender | 3 | Jackie Marshall | Spartanburg Methodist |
| Midfielder | 16 | Kira Hollinghurst | Wake Tech |
| Midfielder | 6 | Naysa Sanchez | Patrick Henry |
| Midfielder | 6 | Elizabeth McGee | Spartanburg Methodist |
| Midfielder | 10 | Courtney Senter | Louisburg |
| Forward | 5 | Inayah Martin | Patrick Henry |
| Forward | 7 | Brittany Heri | Spartanburg Methodist |
Honorable Mention All Region
| Position | Number | Name | School |
| Goalkeeper | 1 | Rachel Howard | Wake Tech |
| Goalkeeper | 0/20 | Rebekah Simpson | Wake Tech |
| Goalkeeper | 17 | Kelsey Cruise | Patrick Henry |
| Goalkeeper | 28 | Amber Perry | USC Salkehatchie |
| Defender | 14 | Sabrina Vaughn | Louisburg |
| Defender | 13 | Anderson O'Neal | Cape Fear |
| Defender | 12 | Cheyenne Floyd | Cape Fear |
| Midfielder | 10 | Kirsten Downey | Patrick Henry |
| Midfielder | 12 | Ashley Prater | USC Salkehatchie |
| Midfielder | 11 | Nina Perry | Cape Fear |
| Forward | 9 | Maria Nunez | USC Salkehatchie |
