Player of the Year: Mila Mzamane; USC Union
Coach of the Year: Kenny Hales; USC Lancaster
First Team All-Region
| Miles Lett | Denmark | Goalkeeper |
| Jack Frost | USC Lancaster | Forward |
| Mila Mzamane | USC Union | Forward |
| Emilo Betancur | Richard Bland | Mid-Field |
| Sam Macy | USC Lancaster | Mid-Field |
| Wesley Mendoza | USC Lancaster | Mid-Field |
| Juan Rodas | USC Union | Mid-Field |
| Ammar Nazih | Richard Bland | Defenders |
| Sam Harrison | USC Lancaster | Defenders |
| Perdro Rocha | USC Union | Defenders |
| Dyvenson Decime | USC Salk | Defenders |
Second Team All-Region
| Juan Montoya | USC Sumter | Goalkeeper |
| Juan Santana | Richard Bland | Forward |
| Luis Peralta | USC Sumter | Forward |
| Salvador Noronha | SWCC | Mid-Field |
| Julien Fodisch | USC Union | Mid-Field |
| Joseph Anderson-Saavedra | USC Salk | Mid-Field |
| Nacho (Ignacio) Gonzales | USC Sumter | Mid-Field |
| Rivaldo Mitchell | SWCC | Defenders |
| Connor Nickerson | Richard Bland | Defenders |
| Andrew Jackson | USC Lancaster | Defenders |
| Emmanuel Zuleta | USC Sumter | Defenders |
Honorable Mention All-Region
| Colby Suber | USC Union | Goalkeeper |
| Brandon Perez | Denmark | Defense |
| Alexander Alvarez | USC Salk | Goalkeeper |
| Xaiver Cabada-Perry | SWCC | Defender |
| Victor Manuel | Richard Bland | Forward |
| Lautaro Guerra | USC Sumter | Defense |
| Ben Richards | USC Lancaster | Mid-Field |
